What is Diabetic Gangrene?
Gangrene is a serious condition that occurs when an organ or tissue dies or decays from a lack of blood. For individuals with diabetes, gangrene is a potential threat due to these individuals’ propensity for certain neuropathies. Open wounds and ulcers, such as those commonly found on the feet of diabetic patients, can lead to gangrene if left untreated, resulting in possible amputation.
In addition to nerve damage, diabetes can severely affect an individual’s blood flow. This lack of blood flow means that open wounds will have a much harder time healing. It’s easy to see how this reduced blood flow, combined with an open wound and an individual’s inability to properly gauge the severity of an injury, and could lead to the rapid development of gangrene.
What are the causes of Gangrene?
- Infection
- Ischemia due to blocked blood vessels
- Diabetes
- Long term smoking
Therapy
Angiogenesis by mobilisation of EPCs (Endothelial Precursor Cells) from the bone marrow and from the pre-existing vessels (capillary growth).
In angiogenesis from pre-existing vessels, endothelial cells from these vessels become motile and proliferate to form capillary sprouts. Regardless of the initiating mechanism, vessel maturation (stablilisation) involves the recruitment of pericytes and smooth muscle cells to form the peri-endothelial layer.
EPCs are mobilised from the bone marrow and may migrate to a site of injury or tumour growth. At these sites, EPCs differentiate and form a mature network by linking to existing vessels.
RESULTS:
Celebrate Life, Unlimited. 
Does this mean that people can save the trauma of amputations due to gangrene? Where can I get more information on the treatment?